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Clinical Research & Biotech projects which can be undertaken with assistance from us

Please find below a list of various projects which can be undertaken by individuals/companies with assistance from us.

• Antimicrobial activity of extract of Murraya koenigii(kadhi patta) on clinical bacterial species
• Antimicrobial and antioxidant activity ofCapparis zeylanica Linn
• Amyloglucosidase derived fromRhizopus niveus for use in degrading gelatinized starch into constituent sugars
• Media optimization for Cephalosporin production
• Comparative study for PHB production from waste (comparison with Alcaligenes)
• Micropropagation of Casia Fistula and to check its antimicrobial activity from its extract
• In vitro propagation and antimicrobial activity of crude extract of Indian spices (ginger, garlic, onion,) on clinical bacterial species
• Comparative study for nitrogen biofertilizers produced using different substrates
• Comparative study for use of different carrier materials for biofertilizer preparation
• Micro propagation of Coleus forskohii- karpur vani and its antimicrobial activity
• Micro propagation of Endangered Tree Oroxylum indicum (Linn.) (bhut-vriksha) Vent.
• Molecular docking consists of predicting how two molecules will interact. This can either be two proteins or one protein and a small compound, such as a new drug. The two main factors that are taken into account are the shape and electrostatics of the two molecules
• Constructing phylogenetic trees. Read an overview of the construction of phylogenetic trees using a neighbour-joining approach. For this project, you will produce a prototype implementation, in Java, of a modern method such as: quartet method, maximum likelihood or maximum parsimony.
• Predicting Cellular Localization. Eukaryotic cells contain several sub-compartments, the Cellular Localization problem consists of predicting which compartment a protein is most likely to be found, on the basis of sequence information alone. The project may consist of a review of the literature and/or a novel analysis (I have access to a data-set that has never been used in a predictive context).
• Isolation, biochemical characterization and preparation of biofertilizer using Rhizobium strains for commercial use
• Mass production of phosphate solublizing biofertilizer from agro-waste
• Media optimization for biofertilizer preparation
• Use of kitchen waste for production of potassium solublizing biofertilizer
• Biodegradation of S-Triazine herbicides by soil microbioganism
• Isolation and characterization of S-triazine herbicides herbicide degrading microbes
• Isolation and characterization of microbes for removal of toxic phenols from industrial effluents
• Isolation and characterization of thermophilic actinomycetes for anti-fungal activity
• Fumaric acid production from waste
• Gluconic acid production by niger
• Invertase from edible baker’s yeast or brewer’s yeast (Saccharomyces cerevisiae)
• Lactase enzyme preparation fromCandida pseudotropicalis for use in hydrolyzing lactose to glucose and galactose
• Expression data + motif discovery. DNA–arrays allows to find genes that are simultaneously expressed. Those genes are most likely co-regulated, i.e. they share a common sequence signal in their promoter region. Daniela Cerna implemented a suffix tree library in Java, in the context of her honours project. Here, we would be re-using the library to help finding conserved motifs.
• Simultaneous alignment and structure prediction for two RNA sequences. Implement a simplified version of dynalign, where the secondary structure prediction is calculated using the Nissinov algorithm; i.e. finds the maximum number of base pairs.
• Lactic acid production from immobilized Lactobacillus
• Media Optimization for curdlan production
• Media optimization for thermostable PHB production
• Optimization of prodigiosin production and evaluation of its bioactivity
• PHB production from salt water isolate
• Production and purification of pectinase by soil isolates and search for better agro-residue for its SSF
• Production and recovery of pullulan by Aerobacidium pullulan
• Micro propagation of Frerea indica.
• To determine the Antimicrobial activity of Limonia acidissima Linn. (Kath Bel or Kabeet) and its micropropagation. Production of Chitinase from agro waste
• Production of extracellular Exoglucanase by Rhizopus oryzae
• Production of laccase by the white-rot fungus Pycnoporus Sanguineus
• Production of lignocellulolytic enzymes
• Production of Poly-3-hydroxyalkanoates (PHA) from the aromatic hydrocarbon styrene by Pseudomonas putida
• Production of Red Pigments by Monascus purpureus in Submerged Culture Effect of substrates on the production of Monascus biopigments by solid-state fermentation and pigment extraction using different solvents
• Production of serratiopeptidase
• Production of useful esterases by varying micro-organism and nutrient source
• Production of useful Glucose oxidase by varying micro-organism and nutrient source
• Production of xylanase from agro waste
• Pullulanase: A Potential Enzyme for Industrial Application by Klebsiella pneumonina
• Thermostable and alkaline tolerant xylanase production
• Use of Agro waste for production of fungal xylanase
• Utilizing Agro waste for microbial thermostable lipase production
• Utilizing Agro waste for production of chitosan by A.niger
• Xanthan Gum Production of Xanthomonas spp. isolated from different Plants
• To determine the antimicrobial activity and micro propagation of
• Production and use of lipase in Bioenergy
• Production of alkaline protease from salt water isolate
• Production of bacitracin by Bacillus subtilis
• Production of Carbohydrase and protease fromBacillus subtilis

 Bio Info Projects

• Database of carbohydrates
• Structure mapping viral proteins to viral genome
• Text mining approach :To find out antigens and epitopes from literature.
• Text mining approach :To find out proteins that are glycosylated.
• Support Vector Machine for classification
• Phylogeny determination
• Annotation using protein profiling
• Phylogeny using Gene order
• Molecular mimicry and autoimmune disease
• Comparison of T cell epitope prediction algorithms
• Antigen discovery using dissimilarity versus the human genome
• Protein contact map
• Comparison of protein secondary structure definition algorithms
• I dentifying and sourcing Novel insecticidal proteins
• Autoimmune disease caused due to molecular mimicry
• A database of protein isoelectric points /carbohydrates/vectors
• Prediction of glycosylation sites.
• Prediction of phosphorylation sites
• Microarray analysis using statistical package “R”
• Text Mining method to extract information from literature.

PTC Projects

• In vitro micro prorogation of  Withania somnifera (L)  Ashwagandha –
• In vitro micro propagation of  Pterocarpus santalinus
• In vitro micro prorogation of musa spp. Banana trees
• In vitro micro propagation of bambusa oldhami
• In vitro micro prorogation of jatropha curcas L.
• In vitro micro propagation of  stevia rebaudiana
• In vitro micro propagation of  trifolium alexandrium and medicago sative sandalwood (sautalum album L.)
• In vitro micro propagations of roseus and solanum nigrum
• In vitro micro prorogation of  gossypium spp.
• In vitro micro propagation of ginger

Amino acid production

• Production of Amino acids from microorganisms isolated from different natural sources.
• Production of Phenylalanine amino acid from Acromobacter spp.
• Production of Glycine amino acid from Pseudomonas spp.

Enzymology

• Bacillus sphaericus: The highest bacterial tannase producer with potential for gallic acid synthesis
• Microbial production of tannase: an enzyme with potential use in food industry
• Recovery of pectolytic enzymes produced by solid state culture of Aspergillus niger
• Production of pectinase enzyme from organisms isolated from ripened fruits.

Genetics

• Isolation of thermopiles from natural habitat and genetic study.
• Isolation pesticide degredating organisms and their identification.

Bioremediation

• Bioremediation is the use of microorganism metabolism to remove pollutants.
• The use of thermophilic bacteria in accelerated hydrocarbon bioremediation.
• Isolation and identification of microorganisms used in bioleaching from environment.
• 4. Biostimulation: study of various components stimulate rate of bioremediation.

Medical Microbiology

• Isolation & Identification of common hospital infection agent in particular geographical zone.
• Isolation & Identification of most common infectious agent from pus.
• Isolation & Identification of most common infectious agent from urine.

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