Clinical Research & Biotech projects which can be undertaken with assistance from us

Please find below a list of various projects which can be undertaken by individuals/companies with assistance from us.
biopharma-project-ideas

  • Antimicrobial activity of extract of Murraya koenigii(kadhi patta) on clinical bacterial species
  • Antimicrobial and antioxidant activity ofCapparis zeylanica Linn
  • Amyloglucosidase derived fromRhizopus niveus for use in degrading gelatinized starch into constituent sugars
  • Media optimization for Cephalosporin production
  • Comparative study for PHB production from waste (comparison with Alcaligenes)
  • Micropropagation of Casia Fistula and to check its antimicrobial activity from its extract
  • In vitro propagation and antimicrobial activity of crude extract of Indian spices (ginger, garlic, onion,) on clinical bacterial species
  • Comparative study for nitrogen biofertilizers produced using different substrates
  • Comparative study for use of different carrier materials for biofertilizer preparation
  • Micro propagation of Coleus forskohii- karpur vani and its antimicrobial activity
  • Micro propagation of Endangered Tree Oroxylum indicum (Linn.) (bhut-vriksha) Vent.
  • Molecular docking consists of predicting how two molecules will interact. This can either be two proteins or one protein and a small compound, such as a new drug. The two main factors that are taken into account are the shape and electrostatics of the two molecules
  • Constructing phylogenetic trees. Read an overview of the construction of phylogenetic trees using a neighbour-joining approach. For this project, you will produce a prototype implementation, in Java, of a modern method such as: quartet method, maximum likelihood or maximum parsimony.
  • Predicting Cellular Localization. Eukaryotic cells contain several sub-compartments, the Cellular Localization problem consists of predicting which compartment a protein is most likely to be found, on the basis of sequence information alone. The project may consist of a review of the literature and/or a novel analysis (I have access to a data-set that has never been used in a predictive context).
  • Isolation, biochemical characterization and preparation of biofertilizer using Rhizobium strains for commercial use
  • Mass production of phosphate solublizing biofertilizer from agro-waste
  • Media optimization for biofertilizer preparation
  • Use of kitchen waste for production of potassium solublizing biofertilizer
  • Biodegradation of S-Triazine herbicides by soil microbioganism
  • Isolation and characterization of S-triazine herbicides herbicide degrading microbes
  • Isolation and characterization of microbes for removal of toxic phenols from industrial effluents
  • Isolation and characterization of thermophilic actinomycetes for anti-fungal activity
  • Fumaric acid production from waste
  • Gluconic acid production by niger
  • Invertase from edible baker’s yeast or brewer’s yeast (Saccharomyces cerevisiae)
  • Lactase enzyme preparation fromCandida pseudotropicalis for use in hydrolyzing lactose to glucose and galactose
  • Expression data + motif discovery. DNA–arrays allows to find genes that are simultaneously expressed. Those genes are most likely co-regulated, i.e. they share a common sequence signal in their promoter region. Daniela Cerna implemented a suffix tree library in Java, in the context of her honours project. Here, we would be re-using the library to help finding conserved motifs.
  • Simultaneous alignment and structure prediction for two RNA sequences. Implement a simplified version of dynalign, where the secondary structure prediction is calculated using the Nissinov algorithm; i.e. finds the maximum number of base pairs.
  • Lactic acid production from immobilized Lactobacillus
  • Media Optimization for curdlan production
  • Media optimization for thermostable PHB production
  • Optimization of prodigiosin production and evaluation of its bioactivity
  • PHB production from salt water isolate
  • Production and purification of pectinase by soil isolates and search for better agro-residue for its SSF
  • Production and recovery of pullulan by Aerobacidium pullulan
  • Micro propagation of Frerea indica.
  • To determine the Antimicrobial activity of Limonia acidissima Linn. (Kath Bel or Kabeet) and its micropropagation. Production of Chitinase from agro waste
  • Production of extracellular Exoglucanase by Rhizopus oryzae
  • Production of laccase by the white-rot fungus Pycnoporus Sanguineus
  • Production of lignocellulolytic enzymes
  • Production of Poly-3-hydroxyalkanoates (PHA) from the aromatic hydrocarbon styrene by Pseudomonas putida
  • Production of Red Pigments by Monascus purpureus in Submerged Culture Effect of substrates on the production of Monascus biopigments by solid-state fermentation and pigment extraction using different solvents
  • Production of serratiopeptidase
  • Production of useful esterases by varying micro-organism and nutrient source
  • Production of useful Glucose oxidase by varying micro-organism and nutrient source
  • Production of xylanase from agro waste
  • Pullulanase: A Potential Enzyme for Industrial Application by Klebsiella pneumonina
  • Thermostable and alkaline tolerant xylanase production
  • Use of Agro waste for production of fungal xylanase
  • Utilizing Agro waste for microbial thermostable lipase production
  • Utilizing Agro waste for production of chitosan by A.niger
  • Xanthan Gum Production of Xanthomonas spp. isolated from different Plants
  • To determine the antimicrobial activity and micro propagation of
  • Production and use of lipase in Bioenergy
  • Production of alkaline protease from salt water isolate
  • Production of bacitracin by Bacillus subtilis
  • Production of Carbohydrase and protease fromBacillus subtilis

 Bio Info Projects

  • Database of carbohydrates
  • Structure mapping viral proteins to viral genome
  • Text mining approach :To find out antigens and epitopes from literature.
  • Text mining approach :To find out proteins that are glycosylated.
  • Support Vector Machine for classification
  • Phylogeny determination
  • Annotation using protein profiling
  • Phylogeny using Gene order
  • Molecular mimicry and autoimmune disease
  • Comparison of T cell epitope prediction algorithms
  • Antigen discovery using dissimilarity versus the human genome
  • Protein contact map
  • Comparison of protein secondary structure definition algorithms
  • I dentifying and sourcing Novel insecticidal proteins
  • Autoimmune disease caused due to molecular mimicry
  • A database of protein isoelectric points /carbohydrates/vectors
  • Prediction of glycosylation sites.
  • Prediction of phosphorylation sites
  • Microarray analysis using statistical package “R”
  • Text Mining method to extract information from literature.

PTC Projects

  • In vitro micro prorogation of  Withania somnifera (L)  Ashwagandha –
  • In vitro micro propagation of  Pterocarpus santalinus
  • In vitro micro prorogation of musa spp. Banana trees
  • In vitro micro propagation of bambusa oldhami
  • In vitro micro prorogation of jatropha curcas L.
  • In vitro micro propagation of  stevia rebaudiana
  • In vitro micro propagation of  trifolium alexandrium and medicago sative sandalwood (sautalum album L.)
  • In vitro micro propagations of roseus and solanum nigrum
  • In vitro micro prorogation of  gossypium spp.
  • In vitro micro propagation of ginger

Amino acid production

  • Production of Amino acids from microorganisms isolated from different natural sources.
  • Production of Phenylalanine amino acid from Acromobacter spp.
  • Production of Glycine amino acid from Pseudomonas spp.

Enzymology

  • Bacillus sphaericus: The highest bacterial tannase producer with potential for gallic acid synthesis
  • Microbial production of tannase: an enzyme with potential use in food industry
  • Recovery of pectolytic enzymes produced by solid state culture of Aspergillus niger
  • Production of pectinase enzyme from organisms isolated from ripened fruits.

Genetics

  • Isolation of thermopiles from natural habitat and genetic study.
  • Isolation pesticide degredating organisms and their identification.

Bioremediation

  • Bioremediation is the use of microorganism metabolism to remove pollutants.
  • The use of thermophilic bacteria in accelerated hydrocarbon bioremediation.
  • Isolation and identification of microorganisms used in bioleaching from environment.
  • 4. Biostimulation: study of various components stimulate rate of bioremediation.

Medical Microbiology

  • Isolation & Identification of common hospital infection agent in particular geographical zone.
  • Isolation & Identification of most common infectious agent from pus.
  • Isolation & Identification of most common infectious agent from urine.

Molecular Biology Incubation Laboratory & Instruments